|
KMID : 0356920190720020164
|
|
Korean Journal of Anesthesiology
2019 Volume.72 No. 2 p.164 ~ p.168
|
|
|
The correlation of heart rate between natural sleep and dexmedetomidine sedation
|
|
Kang Dong-Hee
Lim Chang-Woo
Shim Dong-Jin
Kim Hui-Young
Kim Ji-Wook
Chung Hyung-Joo
Shin Yu-Som
Kim Joo-Duck
Ryu Sie-Jeong
|
|
|
Abstract
|
|
|
Background: Sedation by dexmedetomidine, like natural sleep, often causes bradycardia. We explored the nature of heart rate (HR) changes as they occur during natural sleep versus those occurring during dexmedetomidine sedation.
Methods: The present study included 30 patients who were scheduled to undergo elective surgery with spinal anesthesia. To assess HR and sedation, a pulse oximeter and bispectral index (BIS) monitor were attached to the patient in the ward and the operating room. After measuring HR and BIS at baseline, as the patients slept and once their BIS was below 70, HR and BIS were measured at 5-minute intervals during sleep. Baseline HR and BIS were also recorded before spinal anesthesia measured at 5-minute intervals after dexmedetomidine injection.
Results: During natural sleep, HR changes ranged from 2 to 19 beats/min (13.4 ± 4.4 beats/min), while in dexmedetomidine sedation, HR ranged from 9 to 40 beats/min (25.4 ± 8.5 beats/min). Decrease in HR was significantly correlated between natural sleep and dexmedetomidine sedation (R2 = 0.41, P < 0.001). The lowest HR was reached in 66 min during natural sleep (59 beats/min) and in 13 min with dexmedetomidine sedation (55 beats/min). The time to reach minimum HR was significantly different (P < 0.001), but there was no difference in the lowest HR obtained (P = 0.09).
Conclusions: There was a correlation between the change in HR during natural sleep and dexmedetomidine sedation. The bradycardia that occurs when using dexmedetomidine may be a normal physiologic change, that can be monitored rather than corrected.
|
|
|
KEYWORD
|
|
|
Dexmedetomidine, Heart rate, Sedatives, Sleep, Spinal anesthesia
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
   
|
|